Lysaker P H, Bell M D, Zito W S, Bioty S M
West Haven Veterans Administration Medical Center, Connecticut 06516, USA.
J Nerv Ment Dis. 1995 Nov;183(11):688-92.
While the impact of social learning programs upon social deficits in schizophrenia has been widely studied, less is understood about which patients have the poorest social skills, and among those which patients have deficits most refractory to rehabilitation. To explore these questions, this study compared the symptom levels and performance on neuropsychological testing of 91 subjects with impaired and unimpaired social skills enrolled in a vocational rehabilitation program. After 10 weeks of rehabilitation and a supportive group treatment, social skills among a subsample of 41 subjects with initially impaired social skills were reassessed. Results indicate that subjects with initially impaired social skills had significantly higher levels of negative symptoms. However, multiple regression analysis revealed that cognitive impairments at intake, rather than level of negative symptoms, predicted improvement among subjects with initially impoverished social skills (R2 = .35). Results suggest that level of cognitive impairment is associated with the persistence of social skills deficits in schizophrenia.
虽然社会学习项目对精神分裂症患者社交缺陷的影响已得到广泛研究，但对于哪些患者社交技能最差，以及在这些患者中哪些患者的缺陷最难通过康复治疗改善，我们了解得还较少。为探讨这些问题，本研究比较了91名参加职业康复项目、社交技能受损和未受损的受试者的症状水平及神经心理学测试表现。经过10周的康复治疗和支持性团体治疗后，对41名最初社交技能受损的受试者子样本的社交技能进行了重新评估。结果表明，最初社交技能受损的受试者具有显著更高水平的阴性症状。然而，多元回归分析显示，入组时的认知障碍而非阴性症状水平，预测了最初社交技能较差的受试者的改善情况（R2 = 0.35）。结果表明，认知障碍程度与精神分裂症患者社交技能缺陷的持续存在有关。
