Moreno J A, Baughcum S D, Levy H B, Baer G M
J Gen Virol. 1979 Jan;42(1):219-22. doi: 10.1099/0022-1317-42-1-219.
Mice were inoculated in the left hind footpad with street rabies virus, and 24 h later various types of rabies vaccine were administered intramuscularly in the right leg. The vaccines alone were ineffective in reducing mortality, but when an interferon inducer, polyriboinosinic acid-polyribocytidylic acid complexed to poly-L-lysine (polyICLC), was given along with the vaccines, a marked reduction resulted. The polyICLC-vaccine combination was effective even when it was injected 5 days after infection, suggesting that effective postexposure treatment in man might be successful when given at a comparable late time.
