• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[一种干扰素诱导剂对脑内感染狂犬病街毒小鼠的预防和治疗作用]

[Prophylactic and therapeutic activity of an interferon inducer in mice infected intracerebrally with rabies street virus].

作者信息

Gribencha S V, Nosik N N, Ershov F I, Barinskiĭ I F

出版信息

Vopr Virusol. 1983 Jan-Feb;28(1):71-4.

PMID:6189300
Abstract

Experiments in mice inoculated intracerebrally with street rabies virus demonstrated a protective effect of an interferon inducer (double-stranded RNA of phage f2). A high degree of protection was observed after intracerebral inoculation of the inducer both 24 h before and 4 h after virus infection, with a considerable increase of the average life-span of the animals. Intramuscular and intraperitoneal inoculation of the inducer proved ineffective.

摘要

用街狂犬病毒脑内接种小鼠的实验证明了一种干扰素诱导剂(噬菌体f2的双链RNA)的保护作用。在病毒感染前24小时和感染后4小时脑内接种诱导剂后观察到高度保护作用,动物的平均寿命显著延长。肌肉内和腹腔内接种诱导剂证明无效。

相似文献

1
[Prophylactic and therapeutic activity of an interferon inducer in mice infected intracerebrally with rabies street virus].[一种干扰素诱导剂对脑内感染狂犬病街毒小鼠的预防和治疗作用]
Vopr Virusol. 1983 Jan-Feb;28(1):71-4.
2
[Effectiveness of dsRNA as an interferon inducer in the intramuscular infection of mice with rabies street virus].
Vopr Virusol. 1983 Mar-Apr(2):232-5.
3
[Therapeutic activity of the combined use of an interferon inducer and vaccine in experimental rabies].[干扰素诱导剂与疫苗联合使用在实验性狂犬病中的治疗活性]
Vopr Virusol. 1983 Sep-Oct;28(5):590-4.
4
[Effect of the interferon inducer RFf2 on the course of an infection due to the rabies virus in mice].[干扰素诱导剂RFf2对小鼠狂犬病病毒感染病程的影响]
Vopr Virusol. 1983 Jan-Feb;28(1):67-70.
5
[Effect of the interferon inducer double-stranded RNA on the development of vaccinal antirabies immunity].[干扰素诱导剂双链RNA对疫苗抗狂犬病免疫发育的影响]
Vopr Virusol. 1984 Mar-Apr;29(2):223-7.
6
[Immunostimulating effect of interferon inducers].
Vopr Virusol. 1983 Jul-Aug;28(4):74-9.
7
Further studies on rabies postexposure prophylaxis in mice: a comparison of vaccine with interferon and vaccine.
J Gen Virol. 1979 Jan;42(1):219-22. doi: 10.1099/0022-1317-42-1-219.
8
[Comparative study of the antiviral activity of natural double-stranded RNAs in experimental tick-borne encephalitis].[天然双链RNA在实验性蜱传脑炎中抗病毒活性的比较研究]
Vopr Virusol. 1985 Nov-Dec;30(6):697-700.
9
[Effect of daily immunization and antirabies gamma-globulin on the development of immune T-killers in inbred mice infected with the street rabies virus].[每日免疫及抗狂犬病丙种球蛋白对感染街狂犬病毒的近交系小鼠免疫性T杀伤细胞发育的影响]
Vopr Virusol. 1988 Sep-Oct;33(5):576-80.
10
[Aerosol method of using interferon inducers].[使用干扰素诱导剂的气溶胶方法]
Vopr Virusol. 1980 Jul-Aug(4):473-7.

引用本文的文献

1
Bacteriophage-Derived Double-Stranded RNA Exerts Anti-SARS-CoV-2 Activity In Vitro and in Golden Syrian Hamsters In Vivo.噬菌体衍生的双链RNA在体外和体内金黄地鼠中发挥抗SARS-CoV-2活性。
Pharmaceuticals (Basel). 2022 Aug 25;15(9):1053. doi: 10.3390/ph15091053.