Abrahams S, Leigh P N, Kew J J, Goldstein L H, Lloyd C M, Brooks D J
Department of Psychology, Institute of Psychiatry, London, UK.
J Neurol Sci. 1995 May;129 Suppl:44-6. doi: 10.1016/0022-510x(95)00060-f.
Positron emission tomography (PET) was used to investigate the location of cerebral cortical and subcortical abnormalities in non-demented patients with amyotrophic lateral sclerosis (ALS). Involvement of the frontal lobes was investigated with a task of executive frontal lobe function (verbal fluency/word generation), using a PET activation paradigm. Two groups of ALS patients defined by the presence or absence of cognitive impairment were tested. ALS patients who had cognitive impairments showed a region of cortical and subcortical dysfunction which extended across a wide area of the frontal lobes, and included the insular cortex and thalamic nuclear complex. These findings support the notion that extra-motor involvement is relatively common in ALS and broadens concepts of selective vulnerability in ALS.
正电子发射断层扫描（PET）被用于研究肌萎缩侧索硬化症（ALS）非痴呆患者大脑皮质和皮质下异常的位置。采用PET激活范式，通过执行额叶功能任务（语言流畅性/单词生成）来研究额叶的受累情况。对两组根据是否存在认知障碍定义的ALS患者进行了测试。有认知障碍的ALS患者表现出皮质和皮质下功能障碍区域，该区域横跨额叶的广泛区域，包括岛叶皮质和丘脑核复合体。这些发现支持了这样一种观点，即运动外受累在ALS中相对常见，并拓宽了ALS中选择性易损性的概念。
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