Adamkin D D, Radmacher P, Rosen P
University of Louisville, Department of Pediatrics, Kentucky 40292, USA.
J Perinatol. 1995 Mar-Apr;15(2):108-13.
Twenty preterm infants were randomly assigned to receive either a general-purpose intravenous amino acid solution or a neonatal formula at 1.5 gm/kg/day with 50 nonprotein energy calories for 1 week. Both groups demonstrated similar rates of weight gain and similar liver function test results, but comparison of changes from baseline amino acid values disclosed significant intergroup differences for levels of plasma glycine, taurine, valine, and methionine after 7 days of infusion. Comparison of plasma aminograms of study patients with those of normally growing, enterally fed preterm infants showed that infants who received the neonatal solution had similar amino acid profiles, with the exception of low plasma concentrations of tyrosine and elevated concentrations of threonine. The general-purpose solution, as compared with findings in historic enteral controls, produced low plasma valine, tyrosine, and taurine levels, and elevated levels of glycine and methionine. Advantages with the neonatal amino acid solution include reductions in plasma glycine and methionine levels, plus the provision of taurine. Providing tyrosine remains a problem.
20名早产儿被随机分配，分别接受通用型静脉氨基酸溶液或新生儿配方奶，剂量均为1.5克/千克/天，并搭配50千卡非蛋白质能量，为期1周。两组的体重增加速率和肝功能测试结果相似，但比较输注7天后氨基酸水平相对于基线值的变化发现，两组间血浆甘氨酸、牛磺酸、缬氨酸和蛋氨酸水平存在显著差异。将研究对象的血浆氨基酸谱与正常生长、经肠道喂养的早产儿进行比较，发现接受新生儿配方奶的婴儿除血浆酪氨酸浓度较低和苏氨酸浓度升高外，氨基酸谱相似。与历史上的肠道喂养对照组相比，通用型溶液导致血浆缬氨酸、酪氨酸和牛磺酸水平较低，而甘氨酸和蛋氨酸水平升高。新生儿氨基酸溶液的优势包括降低血浆甘氨酸和蛋氨酸水平，以及补充牛磺酸。但酪氨酸的补充仍是个问题。
