Marlowe N
Department of Neurology, University of New South Wales, Australia.
J Psychosom Res. 1995 Feb;39(2):119-31. doi: 10.1016/0022-3999(94)00072-d.
The central theory of headache was investigated by examining the amplitude of the somatosensory evoked potential (SSEP) in headache sufferers and headache-free controls. The P1-N1 amplitude was found to be greater, and to increase more rapidly with increasing stimulus intensity, for headache subjects than for controls. The N1-P2 amplitude was also found to be larger for headache subjects than for controls, but there was no significant difference between groups on the rate at which this component increased with stimulus intensity. When the P1-N1 and N1-P2 amplitudes were assessed in headache subjects, during and between attacks, no significant differences between conditions were observed. No significant differences between tension and migraine sufferers were observed on either component. It was concluded that the central nervous systems of headache sufferers may be more reactive to somatosensory input than those of headache-free persons and that this might be an important factor in the pathophysiology of headache.
通过检测头痛患者和无头痛对照者的体感诱发电位（SSEP）振幅，对头痛的核心理论进行了研究。结果发现，与对照组相比，头痛患者的P1-N1振幅更大，且随着刺激强度的增加，其增长速度更快。还发现头痛患者的N1-P2振幅也比对照组大，但两组之间该成分随刺激强度增加的速率没有显著差异。在头痛发作期间和发作间隙对头痛患者的P1-N1和N1-P2振幅进行评估时，未观察到不同状态之间存在显著差异。在这两个成分上，紧张性头痛患者和偏头痛患者之间均未观察到显著差异。得出的结论是，与无头痛者相比，头痛患者的中枢神经系统可能对体感输入更具反应性，这可能是头痛病理生理学中的一个重要因素。
