Mutagenic activity of dopamine after nitrosation.
作者信息
Su C, Chen B, Wang S, Liu Z
机构信息
Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, People's Republic of China.
出版信息
Mutat Res. 1995 Jun;347(1):17-9. doi: 10.1016/0165-7992(95)90027-6.
PMID:7596362
Abstract
Dopamine hydrochloride is reported to be a new mutagen precursor in this study. After treatment with nitrite under acidic conditions, dopamine hydrochloride showed direct-acting mutagenicity on Salmonella typhimurium TA100, TA98 and Escherichia coli WP2uvra. The addition of S9 mix did not affect the mutagenicity of nitrosated dopamine significantly in these three strains. Meanwhile, a comparison of the mutagenicity of nitrosated dopamine with nitrosated tyramine was carried out.
摘要
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