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非洲爪蟾胚胎中的初级神经发生受果蝇神经发生基因Delta的一个同源物调控。

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.

作者信息

Chitnis A, Henrique D, Lewis J, Ish-Horowicz D, Kintner C

机构信息

Salk Institute for Biological Studies, San Diego, California 92186, USA.

出版信息

Nature. 1995 Jun 29;375(6534):761-6. doi: 10.1038/375761a0.

DOI:10.1038/375761a0
PMID:7596407
Abstract

X-Delta-1, a Xenopus homologue of the Drosophila Delta gene, is expressed in the early embryonic nervous system in scattered cells that appear to be the prospective primary neurons. Ectopic X-Delta-1 activity inhibits production of primary neurons and interference with endogenous X-Delta-1 activity results in overproduction of primary neurons. These results indicate that the X-Delta-1 protein mediates lateral inhibition delivered by prospective neurons to adjacent cells, and that commitment to a neural fate in vertebrates is regulated by Delta-Notch signalling as in Drosophila.

摘要

X-Delta-1是果蝇Delta基因的非洲爪蟾同源物，在早期胚胎神经系统中表达于散在的细胞中，这些细胞似乎是预期的初级神经元。异位的X-Delta-1活性会抑制初级神经元的产生，而干扰内源性X-Delta-1活性则会导致初级神经元过度产生。这些结果表明，X-Delta-1蛋白介导了预期神经元向相邻细胞传递的侧向抑制，并且脊椎动物中神经命运的决定如同在果蝇中一样，受Delta-Notch信号通路调控。

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Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.非洲爪蟾胚胎中的初级神经发生受果蝇神经发生基因Delta的一个同源物调控。
Nature. 1995 Jun 29;375(6534):761-6. doi: 10.1038/375761a0.
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