Benelli A, Bertolini A, Poggioli R, Menozzi B, Basaglia R, Arletti R
Department of Biomedical Sciences, University of Modena, Italy.
Neuropeptides. 1995 Apr;28(4):251-5. doi: 10.1016/0143-4179(95)90029-2.
Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigation time of the adult rat towards the same juvenile during a second encounter (120 min later) with two peaks of activity, at 10 fg and 1 ng/rat. Larger doses of oxytocin were ineffective. The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin, injected 5 min before oxytocin by the same route and at the same doses, while being ineffective per se, completely abolished the memory-improving effect of a low dose of oxytocin (1 ng/rat) and, on the other hand, turned into memory-improving the effect of a high dose of oxytocin (500 ng/rat).
关于催产素对记忆影响的现有数据往往并不一致。在本研究中发现，成年雄性大鼠在与幼鼠接触5分钟后，立即脑室内注射剂量范围为1飞克至10纳克/大鼠的催产素，在第二次接触（120分钟后）时，成年大鼠对同一只幼鼠的社交探究时间显著减少，有两个活性峰值，分别在10飞克和1纳克/大鼠时。更大剂量的催产素则无效。催产素拮抗剂d(CH2)5Tyr(Me)-Orn8-血管催产素，通过相同途径、相同剂量在催产素注射前5分钟注射，其本身无效，但能完全消除低剂量催产素（1纳克/大鼠）的记忆改善作用，另一方面，却能使高剂量催产素（500纳克/大鼠）的作用转变为记忆改善作用。
