Prozesky L, Kellerman T S, Swart D P, Maartens B P, Schultz R A
Onderstepoort Veterinary Institute, South Africa.
Onderstepoort J Vet Res. 1994 Sep;61(3):247-53.
Previously published results of dosing trials, involving 82 ewes, revealed that 66% of the offspring of dams exposed to cultures of Diplodia maydis in the second trimester of pregnancy and 87% of lambs of ewes exposed in the third trimester, were born dead or died soon afterwards. Spongiform degeneration of myelin of varying degree was present in the brains of all the stillborn and non-viable lambs in these trials. Myelin lamellae were separated at the intraperiod line. The spongiform degeneration occurred throughout the central nervous system in severely affected animals, whereas in mildly affected lambs the lesions had a predilection for the white matter, particularly of the cerebellum and cerebrum. In 28 lambs the spongiform degeneration progressed to lytic necrosis, and hydrocephalus was recorded in two animals.
先前发表的涉及82只母羊的剂量试验结果显示，在妊娠中期接触玉米赤霉病菌培养物的母羊所产后代中，66%出生时即死亡或出生后不久死亡；在妊娠晚期接触病菌的母羊所产羔羊中，87%出生时即死亡或出生后不久死亡。在这些试验中，所有死产和无法存活羔羊的大脑中均出现了不同程度的髓鞘海绵状变性。髓鞘板层在内周期线处分离。在严重受影响的动物中，海绵状变性遍布整个中枢神经系统，而在轻度受影响的羔羊中，病变主要发生在白质，尤其是小脑和大脑的白质。在28只羔羊中，海绵状变性发展为溶解性坏死，两只动物出现脑积水。
