Karwacki M, Ochocka M, Kubiak W
Klinika Hematologii i Chorób Rozrostowych Dzieci AM w Warszawie.
Przegl Epidemiol. 1994;48(4):441-7.
The most common hematological abnormality associated with HIV infection is anaemia. The aetiology is multifactorial and may include the HIV virus itself; the anaemia of chronic diseases (ACD); infection with other viruses, mycobacteria and fungi; medications, especially zidovudine; and even B12 deficiency. Erythropoietin insufficiency is present in all anaemic AIDS patients, probably as a result of the mechanism of ACD. The studies, performed in patients with PGL, ARC and AIDS stages of disease demonstrate that rHuEPO is safe, and in dose of 100-200 U/kg b.w. three times a week can alleviate the anemia in AIDS patients taking AZT whose baseline EPO levels are less than 500 mU/ml.
与HIV感染相关的最常见血液学异常是贫血。病因是多因素的，可能包括HIV病毒本身；慢性病贫血（ACD）；感染其他病毒、分枝杆菌和真菌；药物，尤其是齐多夫定；甚至维生素B12缺乏。所有贫血的艾滋病患者均存在促红细胞生成素不足，这可能是ACD机制导致的。在患有PGL、ARC和艾滋病各疾病阶段的患者中进行的研究表明，重组人促红细胞生成素（rHuEPO）是安全的，每周三次、剂量为100 - 200 U/kg体重可缓解基线促红细胞生成素水平低于500 mU/ml且正在服用齐多夫定的艾滋病患者的贫血症状。
