Ogino T, Ono R, Shimizu W, Ikeda H
Department of Radiology, National Cancer Center Hospital East, Japan.
Radiat Med. 1995 Jan-Feb;13(1):27-9.
To clarify the role of postoperative radiotherapy for adenoid cystic carcinoma of the tracheobronchial system (ACC), we analyzed patients treated at the National Cancer Center Hospital, Tokyo. Seven patients with ACC were treated with resective surgery and postoperative radiotherapy from 1962-1990. None of the primary lesions was completely surgically resected. Postoperative irradiation was delivered by standard fractionation at a dose range of 49.2-72 Gy. Four of seven patients lived more than 5 years, up to 21 years, without local recurrence. In contrast, three other patients who showed recurrence within 2 years died of disease before 5 years. Three of four patients who received postoperative irradiation of 60 Gy or more attained local control. One of three patients who received less than 60 Gy failed locally. A high dose of postoperative radiotherapy for patients with a positive surgical margin of ACC seems to improve local control and result in long-term survival.
为阐明术后放疗在气管支气管系统腺样囊性癌（ACC）中的作用，我们分析了在东京国立癌症中心医院接受治疗的患者。1962年至1990年间，7例ACC患者接受了切除手术及术后放疗。所有原发性病变均未完全手术切除。术后放疗采用标准分割，剂量范围为49.2 - 72 Gy。7例患者中有4例存活超过5年，最长达21年，且无局部复发。相比之下，另外3例在2年内出现复发的患者在5年前死于该疾病。4例接受60 Gy或更高剂量术后放疗的患者中有3例实现了局部控制。3例接受低于60 Gy放疗的患者中有1例局部治疗失败。对于手术切缘阳性的ACC患者，高剂量术后放疗似乎可改善局部控制并实现长期生存。
