Cabrera M E, Labra S, Andrade W, Ossandón E, Barriga F
Hospital del Salvador, Departamento de Medicina, Facultad de Medicina, Universidad de Chile.
Rev Med Chil. 1994 Sep;122(9):1052-5.
We present the clinical and laboratory features of 2 patients with B prolymphocytic leukemia. Both are females of the fifth and seventh decade of life. One had the classical clinical picture of massive splenomegaly and a high white cell count, with characteristic prolymphocytes, and the other was asymptomatic, with a low white cell count. The cells were positive to B cell lineage reagents with strong surface immunoglobuline (Ig) and unreactive to T cell antibodies. Analysis of Ig genes at the DNA level demonstrated that both cases had heavy-chain gene rearrangements, confirming the B-cell origin. These are the first patients of prolymphocytic leukemia described in Chile.
我们报告了2例B原淋巴细胞白血病患者的临床和实验室特征。两名患者均为五、七十岁的女性。其中一名患者具有典型的临床表现，即巨脾和高白细胞计数，伴有特征性的原淋巴细胞；另一名患者无症状，白细胞计数较低。细胞对B细胞系试剂呈阳性反应，表面免疫球蛋白（Ig）强阳性，对T细胞抗体无反应。DNA水平的Ig基因分析表明，两例均有重链基因重排，证实为B细胞起源。这是智利报道的首例原淋巴细胞白血病患者。
