Moodley J, Bhoola V, Duursma J, Pudifin D, Byrne S, Kenoyer D G
MRC/UN Pregnancy Hypertension Unit, Faculty of Medicine, University of Natal, Durban.
S Afr Med J. 1995 Feb;85(2):105-7.
To confirm the association of antiphospholipid antibodies with early onset of severe pre-eclampsia before 30 weeks' gestation.
Thirty-four patients with diastolic blood pressure levels > or = 110 mmHg and at least 2+ proteinuria before the 30th week of pregnancy were randomly chosen for inclusion in the study. Blood samples were taken for assessment of anticardiolipin antibodies (ACAs), lupus anticoagulant, syphilitic serology and antinuclear antibodies. Fifteen normal antenatal patients matched for age, parity and gestational age acted as control subjects.
Four of the 34 women (11.7%) in the study group had elevated levels of both ACAs and lupus anticoagulant, compared with none in the control group. This was not found to be statistically different.
Given the low incidence of positive ACAs in early-onset severe pre-eclampsia it is unlikely that they are implicated in its pathogenesis. It is possible that they represent a small subset of patients with alternative or combined pathology.
证实抗磷脂抗体与妊娠30周前早发型重度子痫前期的关联。
随机选取34例妊娠第30周前舒张压水平≥110 mmHg且至少有2+蛋白尿的患者纳入研究。采集血样以评估抗心磷脂抗体（ACAs）、狼疮抗凝物、梅毒血清学和抗核抗体。15例年龄、产次和孕周匹配的正常产前检查患者作为对照。
研究组34名女性中有4名（11.7%）ACAs和狼疮抗凝物水平升高，而对照组无此情况。未发现有统计学差异。
鉴于早发型重度子痫前期中ACAs阳性的发生率较低，它们不太可能参与其发病机制。它们有可能代表了具有其他或合并病理情况的一小部分患者。
