Branch D W, Andres R, Digre K B, Rote N S, Scott J R
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City.
Obstet Gynecol. 1989 Apr;73(4):541-5.
Over a 3-year period, we studied 43 women who presented with severe preeclampsia prior to 34 weeks' gestation. Seven (16%) had significant levels of antiphospholipid antibodies, whereas none of the normotensive controls of similar gestational age had antiphospholipid antibodies (P less than .001). Three of the seven women with antiphospholipid antibodies suffered the following complications during the peripartum period: 1) cerebral infarction and episodes of transient monocular blindness; 2) pulmonary embolism, deep venous thrombosis, and an autoimmune flare in the postpartum period; and 3) transient monocular blindness and amnesia after delivery. Our experience suggests that antiphospholipid antibodies are found in a substantial proportion of cases of early-onset severe preeclampsia and have important clinical implications. We suggest that patients with early-onset severe preeclampsia be screened for antiphospholipid antibodies; if antibodies are detected, these women should be considered for prophylactic anticoagulation therapy.
在3年的时间里，我们研究了43例在妊娠34周前出现重度子痫前期的女性。其中7例（16%）抗磷脂抗体水平显著，而相似孕周的血压正常对照组中无一例有抗磷脂抗体（P<0.001）。7例有抗磷脂抗体的女性中有3例在围产期出现了以下并发症：1）脑梗死和一过性单眼盲发作；2）肺栓塞、深静脉血栓形成以及产后自身免疫性发作；3）产后一过性单眼盲和失忆。我们的经验表明，相当一部分早发型重度子痫前期病例中可检测到抗磷脂抗体，且具有重要的临床意义。我们建议对早发型重度子痫前期患者进行抗磷脂抗体筛查；如果检测到抗体，这些女性应考虑接受预防性抗凝治疗。
