Gene therapy for respiratory diseases: potential applications and difficulties.
作者信息
Alton E W, Geddes D M
出版信息
Thorax. 1995 May;50(5):484-6. doi: 10.1136/thx.50.5.484.
Abstract
摘要
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In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors.使用复制缺陷型重组腺病毒载体在正常未受损血管中的体内基因转移和表达。
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Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice.来自人类SP-C基因的转录元件指导转基因小鼠原始呼吸上皮中的基因表达。
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Clinical implications of the p53 tumor-suppressor gene.p53肿瘤抑制基因的临床意义。
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Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.逆转录病毒载体介导的K-ras反义RNA导入人肺癌细胞可抑制恶性表型的表达。
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Transfer and expression of the human interleukin-4 gene in carcinoma and stromal cell lines derived from lung cancer patients.人白细胞介素-4基因在源自肺癌患者的癌细胞系和基质细胞系中的转移与表达。
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Lung gene therapy: in vivo adenovirus-mediated gene transfer to rhesus monkey airway epithelium.
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Pulmonary autograft in children: realized growth potential.儿童肺动脉自体移植：实现的生长潜力。
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Immunotherapy via gene therapy: comparison of the effects of tumor cells transduced with the interleukin-2, interleukin-6, or interferon-gamma genes.通过基因疗法进行免疫治疗：白细胞介素-2、白细胞介素-6或γ-干扰素基因转导的肿瘤细胞的效果比较
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Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis.腺病毒介导的基因转移可短暂纠正囊性纤维化患者鼻上皮细胞中的氯转运缺陷。
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