• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

人类基因组中的内源性逆转录病毒——一种观点

Endogenous retroviruses in the human genome--a point of view.

作者信息

Becker Y

机构信息

Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

出版信息

Virus Genes. 1995 Feb;9(3):211-8. doi: 10.1007/BF01702877.

DOI:10.1007/BF01702877
PMID:7597800
Abstract

The search for retroviruses in human cancer cells has advanced with the discoveries of the retroviral reverse transcriptase, DNA hybridization and sequencing techniques, and polymerase chain reaction (PCR) technology. Each technological advancement has led to a better refinement and a better understanding of latent endogenous retroviruses in the human genome. With the recent developments in the Human Genome Project it is to be expected that additional information will be obtained on the role and function of these human retroviruses, their ancestral origin and, if possible, their involvement as a source for emerging new retroviruses.

摘要

随着逆转录病毒逆转录酶、DNA杂交和测序技术以及聚合酶链反应(PCR)技术的发现,在人类癌细胞中寻找逆转录病毒的研究取得了进展。每一项技术进步都使人们对人类基因组中潜伏的内源性逆转录病毒有了更好的细化和理解。随着人类基因组计划的最新进展,可以预期将获得更多关于这些人类逆转录病毒的作用和功能、它们的祖先起源,以及如果可能的话,它们作为新兴新逆转录病毒来源的参与情况的信息。

相似文献

1
Endogenous retroviruses in the human genome--a point of view.人类基因组中的内源性逆转录病毒——一种观点
Virus Genes. 1995 Feb;9(3):211-8. doi: 10.1007/BF01702877.
2
What's the host and what's the microbe? The Marjory Stephenson Prize Lecture 2015.何为宿主,何为微生物?2015年马乔里·斯蒂芬森奖讲座
J Gen Virol. 2015 Sep;96(9):2501-2510. doi: 10.1099/jgv.0.000220. Epub 2015 Jul 3.
3
The discovery of endogenous retroviruses.内源性逆转录病毒的发现。
Retrovirology. 2006 Oct 3;3:67. doi: 10.1186/1742-4690-3-67.
4
Human endogenous retroviruses.人类内源性逆转录病毒
Leukemia. 1988 Dec;2(12 Suppl):167S-177S.
5
Genetic reassortment and patch repair by recombination in retroviruses.逆转录病毒中通过重组进行的基因重排和补丁修复。
J Biomed Sci. 2000 Mar-Apr;7(2):77-99. doi: 10.1007/BF02256615.
6
Identification of endogenous retroviral sequences based on modular organization: proviral structure at the SSAV1 locus.基于模块化组织鉴定内源性逆转录病毒序列:SSAV1基因座处的前病毒结构
Genomics. 1997 Jul 1;43(1):52-61. doi: 10.1006/geno.1997.4790.
7
PCR and reverse dot hybridization for the detection of endogenous retroviral transcripts.
J Virol Methods. 1994 Mar;46(3):333-48. doi: 10.1016/0166-0934(94)90004-3.
8
Evolution of endogenous retrovirus-like elements of the woolly mammoth (Mammuthus primigenius) and its relatives.猛犸象(Mammuthus primigenius)及其亲属的内源性逆转录病毒样元件的进化
Mol Biol Evol. 2001 May;18(5):840-7. doi: 10.1093/oxfordjournals.molbev.a003865.
9
Regulated expression of retroviruses and their oncogenes: models for tumor suppression.逆转录病毒及其癌基因的调控表达:肿瘤抑制模型
Immunol Ser. 1990;51:49-73.
10
Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site.利用缺陷型逆转录病毒通过随机插入诱变诱导人乳腺癌细胞产生抗雌激素耐药性:常见整合位点bcar-1的鉴定
Mol Endocrinol. 1993 Jul;7(7):870-8. doi: 10.1210/mend.7.7.8413311.

引用本文的文献

1
Human endogenous retrovirus-K(II) envelope induction protects neurons during HIV/AIDS.人类内源性逆转录病毒-K(II)包膜诱导在艾滋病病毒/艾滋病期间保护神经元。
PLoS One. 2014 Jul 2;9(7):e97984. doi: 10.1371/journal.pone.0097984. eCollection 2014.
2
Evolution and biological significance of human retroelements.人类逆转录元件的进化及其生物学意义。
Virus Genes. 1995;11(2-3):133-45. doi: 10.1007/BF01728654.
3
Gene transfer by viral vectors for gene therapy.用于基因治疗的病毒载体介导的基因转移。

本文引用的文献

1
Presence of env genes in members of the RTVL-H family of human endogenous retrovirus-like elements.人类内源性逆转录病毒样元件RTVL-H家族成员中env基因的存在。
Virology. 1993 Jan;192(1):52-61. doi: 10.1006/viro.1993.1007.
2
Human endogenous retroviral element K10 (HERV-K10) encodes a full-length gag homologous 73-kDa protein and a functional protease.人类内源性逆转录病毒元件K10(HERV-K10)编码一种全长73 kDa的gag同源蛋白和一种功能性蛋白酶。
AIDS Res Hum Retroviruses. 1993 Apr;9(4):343-50. doi: 10.1089/aid.1993.9.343.
3
A general method for the identification of transcribed retrovirus sequences (R-U5 PCR) reveals the expression of the human endogenous retrovirus loci HERV-H and HERV-K in teratocarcinoma cells.
J Mol Med (Berl). 1995 Mar;73(3):103-5. doi: 10.1007/BF00198236.
一种用于鉴定转录逆转录病毒序列的通用方法(R-U5 PCR)揭示了人内源性逆转录病毒基因座HERV-H和HERV-K在畸胎瘤细胞中的表达。
Virology. 1993 Feb;192(2):501-11. doi: 10.1006/viro.1993.1066.
4
Sequence variation of human endogenous retrovirus ERV9-related elements in an env region corresponding to an immunosuppressive peptide: transcription in normal and neoplastic cells.与免疫抑制肽相对应的env区域中人类内源性逆转录病毒ERV9相关元件的序列变异:在正常细胞和肿瘤细胞中的转录
J Virol. 1993 Feb;67(2):1122-6. doi: 10.1128/JVI.67.2.1122-1126.1993.
5
Antibodies in human sera recognizing a recombinant outer membrane protein encoded by the envelope gene of the human endogenous retrovirus K.人血清中识别由人类内源性逆转录病毒K包膜基因编码的重组外膜蛋白的抗体。
AIDS Res Hum Retroviruses. 1993 Jul;9(7):687-94. doi: 10.1089/aid.1993.9.687.
6
Evidence for a functional subclass of the RTVL-H family of human endogenous retrovirus-like sequences.人类内源性逆转录病毒样序列RTVL-H家族功能亚类的证据。
J Virol. 1993 Jun;67(6):2981-9. doi: 10.1128/JVI.67.6.2981-2989.1993.
7
Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene.一种人类内源性逆转录病毒与一个新的磷脂酶A2相关基因的剪接。
Nucleic Acids Res. 1993 Jan 11;21(1):135-43. doi: 10.1093/nar/21.1.135.
8
The human endogenous retrovirus ERV-3 is upregulated in differentiating placental trophoblast cells.人类内源性逆转录病毒ERV-3在胎盘滋养层细胞分化过程中上调。
Virology. 1993 Oct;196(2):905-9. doi: 10.1006/viro.1993.1556.
9
Recent evolutionary expansion of a subfamily of RTVL-H human endogenous retrovirus-like elements.RTVL-H人类内源性逆转录病毒样元件一个亚家族的近期进化扩张。
Virology. 1993 Oct;196(2):778-88. doi: 10.1006/viro.1993.1535.
10
Evidence that HERV-K is the endogenous retrovirus sequence that codes for the human teratocarcinoma-derived retrovirus HTDV.有证据表明,人内源性逆转录病毒K(HERV-K)是编码源自人畸胎癌的逆转录病毒HTDV的内源性逆转录病毒序列。
Virology. 1993 Sep;196(1):349-53. doi: 10.1006/viro.1993.1487.