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[T2 - T3期喉癌侵犯环状软骨]

[Invasion of cricoid cartilage by T2-T3 laryngeal cancer].

作者信息

Fiorella R, Di Nicola V, Resta L

机构信息

Istituto Policattedra di Otorinolaringoiatria, Università di Bari.

出版信息

Acta Otorhinolaryngol Ital. 1995 Feb;15(1):21-7.

PMID:7597899
Abstract

This paper reports a study of microscopic infiltration of the cartilage of the cricoid carried out in 335 patients with T2-T3 carcinomas of the larynx who had undergone total laryngectomy. The results of the investigation revealed microscopic infiltration of the cricoid cartilage in 12% (14/335) of the cases examined. The incidence, however, was much higher in those cases of extension to the hypoglottis (28% vs 5%, p < 0.0001) or in cases of an even greater extension of the tumor (13% vs 7%). In the 161 patients with neoplasias situated in the glottis, there was cricoid invasion in 30 cases regardless of the tumor class. However, with regard to cases with extension to the hypoglottis, a higher incidence of cricoid infiltration (20% vs 8%, p < 0.002) for all T classes was observed. As for as those cases with neoplasias in the supraglottis are concerned, there were no patients classified T2 (0/50) with cricoid infiltration against 8% in T3 subjects (10/124). In these subjects extension to the hypoglottis led to microscopic invasion of the cricoid cartilage in a greater number of patients (31% vs 3%, p < 0.0001). These observations confirm that microscopic infiltration of the cartilagenous skeleton of the larynx, especially of the cricoid, is relatively frequent. Factor of even higher risk are occurrence in the glottis and, in all the situations examined, extension to the hypoglottis. In addition, except in cases of vestibular T2, there is a 5 to 8% possibility of microscopic infiltration of cricoid cartilage even in the absence of clinical signs of hypoglottic invasion.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

本文报告了一项针对335例接受全喉切除术的T2 - T3期喉癌患者环状软骨微观浸润情况的研究。调查结果显示,在检查的病例中,12%(14/335)存在环状软骨微观浸润。然而,声门下扩展的病例中这一发生率要高得多(28% 对比5%,p < 0.0001),或者肿瘤扩展程度更大的病例中也是如此(13% 对比7%)。在161例声门区肿瘤患者中,无论肿瘤分级如何,有30例存在环状软骨侵犯。然而,对于扩展至声门下的病例,所有T分级中环状软骨浸润的发生率更高(20% 对比8%,p < 0.002)。至于声门上区肿瘤的病例,没有T2分级的患者发生环状软骨浸润(0/50),而T3分级的患者中有8%(10/124)发生。在这些患者中,扩展至声门下导致更多患者出现环状软骨微观浸润(31% 对比3%,p < 0.0001)。这些观察结果证实,喉软骨支架,尤其是环状软骨的微观浸润相对常见。更高风险因素是肿瘤发生在声门区,以及在所有检查情况下扩展至声门下。此外,除了前庭T2病例外,即使没有声门下侵犯的临床体征,环状软骨也有5%至8%的可能性发生微观浸润。(摘要截选至250字)

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