Brandenburg J H, Condon K G, Frank T W
Otolaryngol Head Neck Surg. 1986 Sep;95(2):213-8. doi: 10.1177/019459988609500215.
Serial coronal sections of 89 wide-field laryngectomies were examined. Twenty were specimens obtained from laryngectomies to treat patients for whom primary radiation therapy failed to cure early laryngeal cancer. These specimens were compared to 69 specimens from laryngectomies for T3 and T4 laryngeal cancers. The irradiation-failure group showed a significantly greater invasion of cartilage and extension into subglottic areas. The extension of tumors along blood vessels and mucous glands appeared to contribute to the spread of tumors in the irradiation-failure group. These findings have implications for the surgical management of irradiation failures in the treatment of laryngeal cancers.
对89例全喉切除术的连续冠状切片进行了检查。其中20例标本取自全喉切除术，用于治疗原发性放射治疗未能治愈的早期喉癌患者。将这些标本与69例T3和T4期喉癌全喉切除术的标本进行比较。放疗失败组软骨侵犯和向声门下区扩展的情况明显更严重。肿瘤沿血管和黏液腺的扩展似乎促使了放疗失败组肿瘤的扩散。这些发现对喉癌放疗失败的手术治疗具有启示意义。
