Sun F, Liu T P
Department of Pharmacology, Nanjing Medical University, China.
Zhongguo Yao Li Xue Bao. 1995 Mar;16(2):145-8.
To study the effects of tetrandrine (Tet) vs nicardipine (Nic) on cerebral ischemia-reperfusion damages.
Cerebral ischemia was produced by 10-min occlusion of bilateral carotid arteries followed by 5-min reperfusion in gerbils. The changes in electroencephalogram (EEG), calcium and water contents, lipid peroxide (LPO) content and ultrastructure in gerbil brains were compared.
Pretreatment with Tet (15 mg.kg-1, i.v.) and Nic (0.25 mg.kg-1, i.v.) enhanced the recovery of EEG amplitude, reduced the calcium (151.2 +/- 1.1 and 155.3 +/- 2.4 mg/kg dry wt in Tet and Nic groups vs 193 +/- 8 mg/kg dry wt in ischemia-reperfusion group, P < 0.05) and water contents, attenuated the increase in LPO content (293 +/- 29 and 276 +/- 23 mumol.kg-1 wet wt in Tet and Nic groups vs 427 +/- 24 mumol.kg-1 wet wt in ischemia-reperfusion group, P < 0.01), and diminished the ultrastructural abnormalities of cortex and hippocampus in gerbil brain during ischemia and reperfusion.
Tet and Nic had protective effects against ischemia-reperfusion brain damages in gerbils. The effects of Tet were similar to, but less potent than those of Nic.
研究粉防己碱（Tet）与尼卡地平（Nic）对脑缺血再灌注损伤的影响。
通过结扎沙土鼠双侧颈动脉10分钟，然后再灌注5分钟来制造脑缺血模型。比较沙土鼠脑电（EEG）、钙和水含量、脂质过氧化物（LPO）含量及超微结构的变化。
Tet（15mg·kg-1，静脉注射）和Nic（0.25mg·kg-1，静脉注射）预处理可增强EEG波幅的恢复，降低钙（Tet组和Nic组分别为151.2±1.1和155.3±2.4mg/kg干重，缺血再灌注组为193±8mg/kg干重，P<0.05）和水含量，减轻LPO含量的增加（Tet组和Nic组分别为293±29和276±23μmol·kg-1湿重，缺血再灌注组为427±24μmol·kg-1湿重，P<0.01），并减轻沙土鼠脑缺血及再灌注期间皮质和海马的超微结构异常。
Tet和Nic对沙土鼠脑缺血再灌注损伤具有保护作用。Tet的作用与Nic相似，但效力较弱。
