He M X, Ke J, Li Z G, Liu F Z
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
Zhongguo Yao Li Xue Bao. 1996 Jul;17(4):309-10.
To study the effect of nimodipine (Nim) on ischemic cerebral damage.
The four-vessel occlusion method was performed on rats. Monoamines were measured by fluorospectrophotometry.
Intraperitoneal injection of Nim 0.75 and 1.5 mg.kg-1 quickened the recovery of EEG changes to 19 +/- 3 and 17 +/- 4 min (P < 0.01), respectively. Nim reduced the decreases of monoamines (NE, DA, 5-HT, and 5-HIAA) contents after 30-min cerebral ischemia and 1-h reperfusion.
Nim protects the brain from ischemic damage.
