自发性高血压大鼠血小板体外神经肽Y释放增加。
Increase of release of neuropeptide Y in vitro from platelets of spontaneously hypertensive rats.
作者信息
Chen S H, Han Q D
机构信息
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Mar;16(2):149-52.
AIM
To investigate the pathophysiological role of platelet neuropeptide Y (NPY) in hypertension.
METHODS
The content of NPY in plasma and platelets from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKR) were measured by radioimmunoassay.
RESULTS
There was no difference in NPY concentration between SHR plasma and WKR plasma (2.1 +/- 1.0 vs 1.8 + 1.0 microgram.L-1), but higher amounts of NPY in SHR platelets than in WKR platelets (32 +/- 6 vs 22 +/- 9 micrograms.L-1, P < 0.05). The platelet aggregation and the release of NPY from platelets induced by thrombin and collagen were increased in SHR; ADP did not cause NPY release from platelets, although it produced severe aggregation in both SHR and WKR.
CONCLUSION
The content of NPY in platelets and thrombin- and collagen-induced NPY release from platelets are higher in SHR than in WKR.
目的
研究血小板神经肽Y（NPY）在高血压发病机制中的作用。
方法
采用放射免疫分析法测定自发性高血压大鼠（SHR）和Wistar - Kyoto大鼠（WKR）血浆及血小板中NPY的含量。
结果
SHR血浆和WKR血浆中NPY浓度无差异（2.1±1.0对1.8 + 1.0微克·升-1），但SHR血小板中NPY含量高于WKR血小板（32±6对22±9微克·升-1，P<0.05）。SHR中凝血酶和胶原诱导的血小板聚集及血小板NPY释放增加；ADP虽在SHR和WKR中均引起严重聚集，但不引起血小板NPY释放。
结论
SHR血小板中NPY含量以及凝血酶和胶原诱导的血小板NPY释放均高于WKR。
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