组氨酸可改善大鼠局部血栓性脑缺血期间的脑水肿和心脏功能障碍。
Histidine ameliorated brain edema and cardiac dysfunction during local thrombotic cerebral ischemia in rats.
作者信息
Li S Q, Han H, He J
机构信息
Department of Pathophysiology, Kunming Medical College, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Mar;16(2):156-9.
AIM
To observe the effects of histidine (i.v. 5 mg.kg-1) on brain edema and cardiac disturbance after cerebral thrombosis.
METHODS
Regional cerebral thrombosis was induced by photochemical method in rats.
RESULTS
It was showed that the brain water content increased markedly (85.6 +/- 3.8%, P < 0.01); the left ventricular systolic pressure (LVSP, 17.9 +/- 1.5 kPa) and the maximal left ventricular contractility decreased (+dp/dtmax 645 +/- 110 kPa and -dp/dtmax 473 +/- 106 kPa, P < 0.05). In rats treated with histidine after photochemical reaction, the brain water content decreased (81.5 +/- 2.0%) while LVSP (21.2 +/- 1.1 kPa) and left ventricular +dp/dtmax and -dp/dtmax increased markedly (777 +/- 144 kPa and 604 +/- 157 kPa, respectively).
CONCLUSION
Histidine has protective effects on the brain and cardiac function during cerebral thrombosis.
目的
观察组氨酸（静脉注射5mg·kg-1）对脑血栓形成后脑水肿和心脏功能紊乱的影响。
方法
采用光化学法诱导大鼠局部脑血栓形成。
结果
结果显示，脑含水量显著增加（85.6±3.8%，P<0.01）；左心室收缩压（LVSP，17.9±1.5kPa）及左心室最大收缩力降低（+dp/dtmax 645±110kPa，-dp/dtmax 473±106kPa，P<0.05）。光化学反应后用组氨酸治疗的大鼠，脑含水量降低（81.5±2.0%），而LVSP（21.2±1.1kPa）及左心室+dp/dtmax和-dp/dtmax显著增加（分别为777±144kPa和604±157kPa）。
结论
组氨酸在脑血栓形成过程中对脑和心脏功能具有保护作用。
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