营养物质、信号转导与致癌作用

Nutrients, signal transduction and carcinogenesis.

作者信息

Zeisel S H

机构信息

Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill 27599-7400, USA.

出版信息

Adv Exp Med Biol. 1995;369:175-83. doi: 10.1007/978-1-4615-1957-7_16.

DOI:10.1007/978-1-4615-1957-7_16

PMID:7598005

Abstract

Choline phospholipids play major roles in cellular regulation in addition to their essential function as structural components of membranes and lipoproteins. The unique functions of choline phospholipids as hormones (platelet activating factor, 1-alkyl, 2-acetylphosphatidylcholine, PAF) and sources (phosphatidylcholine, sphingolipids) of second messengers (sphingosine, diacylglycerol, lysophospholipids, arachidonic acid and its metabolites) may explain how dietary choline influences normal physiological processes as well as a diverse group of pathological processes, including carcinogenesis.

摘要

胆碱磷脂除了作为膜和脂蛋白的结构成分发挥基本功能外，还在细胞调节中起主要作用。胆碱磷脂作为激素（血小板活化因子，1-烷基，2-乙酰磷脂酰胆碱，PAF）和第二信使（鞘氨醇、二酰甘油、溶血磷脂、花生四烯酸及其代谢产物）的来源（磷脂酰胆碱、鞘脂）所具有的独特功能，可能解释了膳食胆碱如何影响正常生理过程以及包括致癌作用在内的多种病理过程。