Kabat G C, Stellman S D, Wynder E L
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461-1601, USA.
Am J Epidemiol. 1995 Jul 15;142(2):141-8. doi: 10.1093/oxfordjournals.aje.a117612.
To assess the relation between exposure to environmental tobacco smoke throughout life and lung cancer in lifetime nonsmokers, the authors conducted in-person interviews with 41 male and 69 female never-smoking lung cancer cases and 117 male and 187 female never-smoking controls between 1983 and 1990 as part of a hospital-based case-control study of tobacco-related cancers. Cases had newly diagnosed, histologically confirmed primary carcinoma of the lung. Controls were matched to cases on age (+/- 5 years), sex, race, hospital, and year of interview. Subjects were asked about environmental tobacco smoke exposure in childhood, in adulthood at home, in different jobs, and in transportation and social situations. In addition to amount smoked by family members in the subject's presence, subjects were asked to rate the intensity of each exposure, and married subjects were asked whether their spouse smoked in the bedroom. Several independent indicators of exposure to smoking by spouses were strongly correlated, thereby increasing confidence in the classification of exposure status. The reproducibility of environmental tobacco smoke variables was good for qualitative measures (yes/no), in agreement with previous studies. There were few associations of exposure in specific settings with lung cancer. Males whose wives smoked had odds ratio of 1.60 (95% confidence interval (CI) 0.67-3.82) and females whose husbands smoked had an odds ratio of 1.08 (95% CI 0.60-1.94). While this study had limited sample size, the pattern of odds ratios shows little indication of an association of environmental tobacco smoke with lung cancer in nonsmokers.
为评估终生不吸烟者一生中接触环境烟草烟雾与肺癌之间的关系，作为一项基于医院的烟草相关癌症病例对照研究的一部分，作者于1983年至1990年间对41例男性和69例女性终生不吸烟的肺癌患者以及117例男性和187例女性终生不吸烟的对照者进行了面对面访谈。病例为新诊断的、经组织学确诊的原发性肺癌。对照者在年龄（±5岁）、性别、种族、医院和访谈年份方面与病例进行匹配。受试者被问及童年时期、成年后在家中、不同工作场所、交通和社交场合中接触环境烟草烟雾的情况。除了家庭成员在受试者面前的吸烟量外，还要求受试者对每次接触的强度进行评分，并询问已婚受试者其配偶是否在卧室吸烟。配偶吸烟接触的几个独立指标之间高度相关，从而增强了对接触状态分类的信心。与先前的研究一致，环境烟草烟雾变量在定性测量（是/否）方面的可重复性良好。在特定环境中的接触与肺癌之间几乎没有关联。妻子吸烟的男性的比值比为1.60（95%置信区间（CI）0.67 - 3.82），丈夫吸烟的女性的比值比为1.08（95%CI 0.60 - 1.94）。虽然这项研究的样本量有限，但比值比的模式几乎没有显示出环境烟草烟雾与不吸烟者肺癌之间存在关联的迹象。
