干扰素-γ在传染病治疗中的应用

Interferon-gamma in the management of infectious diseases.

作者信息

Gallin J I, Farber J M, Holland S M, Nutman T B

机构信息

Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1504, USA.

出版信息

Ann Intern Med. 1995 Aug 1;123(3):216-24. doi: 10.7326/0003-4819-123-3-199508010-00009.

DOI:10.7326/0003-4819-123-3-199508010-00009

PMID:7598304

Abstract

Interferon-gamma has pleiotropic adjuvant effects on host defenses. These effects have made interferon-gamma particularly useful for enhancing host defenses in patients with chronic granulomatous disease of childhood and thus for reducing the incidence of life-threatening infections in these patients. Increasingly, data suggest that interferon-gamma will be useful for treating infections characterized by intracellular persistence in macrophages, such as toxoplasmosis, leishmaniasis, and mycobacteriosis. Interferon-gamma is emerging as an important cytokine for use in the treatment of infectious diseases.

摘要

γ干扰素对宿主防御具有多效性佐剂作用。这些作用使得γ干扰素在增强儿童慢性肉芽肿病患者的宿主防御方面特别有用，从而降低这些患者危及生命感染的发生率。越来越多的数据表明，γ干扰素将有助于治疗以巨噬细胞内持续性感染为特征的疾病，如弓形虫病、利什曼病和分枝杆菌病。γ干扰素正成为治疗传染病的一种重要细胞因子。