Wong G W, Leung S S, Kwok M M, Oppenheimer S J
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
Ann Trop Paediatr. 1995;15(1):27-31. doi: 10.1080/02724936.1995.11747745.
In a 9-year retrospective review of goitre in Chinese children in Hong Kong, 84 children and adolescents were identified. There was a female predominance with a male:female ratio of 1:5.5. The majority of patients (95%) were found to have diffuse enlargement of the thyroid gland. Forty-nine were found to have Graves' disease. The mean age of presentation of patients with Graves' disease was 11.34 years. Forty-three of them were found to have thyroid autoantibodies. Only two cases of autoimmune thyroiditis with thyroid autoantibodies were diagnosed. The other causes of goitre include simple colloid goitre, multinodular goitre and suppurative thyroiditis. The spectrum of disease causing goitre in Chinese children is thus quite different from that reported in Caucasian children in developed countries. Further studies are necessary to define the genetic or environmental factors resulting in the observed differences.
在一项对香港中国儿童甲状腺肿的9年回顾性研究中，共识别出84名儿童和青少年。女性占主导，男女比例为1:5.5。大多数患者（95%）被发现甲状腺弥漫性肿大。49例被诊断为格雷夫斯病。格雷夫斯病患者的平均就诊年龄为11.34岁。其中43例被发现有甲状腺自身抗体。仅诊断出2例伴有甲状腺自身抗体的自身免疫性甲状腺炎。甲状腺肿的其他病因包括单纯性胶样甲状腺肿、多结节性甲状腺肿和化脓性甲状腺炎。因此，中国儿童甲状腺肿的疾病谱与发达国家白种儿童报道的情况有很大不同。有必要进一步研究以确定导致观察到的差异的遗传或环境因素。
