Fariña L A, Palou Redorta J, Chechile Toniolo G
Urology Department, Fundacion Puigvert, Barcelona, Spain.
Arch Esp Urol. 1995 May;48(4):418-9.
Drug-induced lithiasis was well-known some years ago, when sulfonamides poorly soluble in urine were in use. Now, they are again in use for some opportunistic AIDS-related infections. We report herein the case of an AIDS patient, treated with sulfadiazine because of Nocardia pneumonia, that came to the emergency room in acute renal failure.
METHODS/RESULTS: Obstructive uropathy due to radiolucent calculi was suspected and retrograde ureteral catheterization was necessary. The calculi recovered were identified as N-acetyl sulfadiazine by infrared spectrophotometry.
Rapid improvement can be achieved in these patients when the drug is discontinued or decrease and systemic fluid and urine alkalinization are started.
药物性结石病在多年前就已为人所知，当时使用的是在尿液中溶解度低的磺胺类药物。如今，它们再次被用于一些与艾滋病相关的机会性感染。我们在此报告一例艾滋病患者，因诺卡菌肺炎接受磺胺嘧啶治疗，后因急性肾衰竭被送往急诊室。
方法/结果：怀疑是透X线结石导致的梗阻性尿路病，因此有必要进行逆行输尿管插管。回收的结石通过红外分光光度法鉴定为N - 乙酰磺胺嘧啶。
当停用药物或减少用药剂量，并开始进行全身补液和尿液碱化时，这些患者的病情可迅速改善。
