人肺癌的成功异种移植与转移表型相关。

Successful xenotransplantation of human lung cancer correlates with the metastatic phenotype.

作者信息

Johnson J R, Hammond W G, Benfield J R, Tesluk H

机构信息

Division of Cardiothoracic Surgery, University of California, Davis, School of Medicine, Sacramento 95817, USA.

出版信息

Ann Thorac Surg. 1995 Jul;60(1):32-6; discussion 36-7.

PMID:7598618

Abstract

BACKGROUND

Occult micrometastases could explain deaths from stage I non-small cell lung cancer (NSCLC) after complete resections. If patients who have occult metastases could be identified, systemic therapy might be beneficial.

METHODS

Non-small cell lung cancers from 81 patients in stages I, II, and III were transplanted to nude beige mice. Mean follow-up was 22.5 months (2 to 61 months).

RESULTS

Twenty-one xenotransplants successfully took, and seven metastasized in the nude mice. Neither the predominant cell type nor the incidence of lymph node metastases correlated with the results of xenotransplantation. Of the 21 patients whose NSCLCs took in xenotransplantation, 13 (61.9%) have had development of metastases, and 9 (42.9%) have died of the cancer. Among the 57 patients whose NSCLCs did not take, 14 (24.6%) have had development of metastases, and 9 (15.8%) have died of their cancer. The higher incidence of metastases in association with xenotransplant take is significant (p = 0.0032).

CONCLUSIONS

Patients whose NSCLCs take in xenotransplantation are at high risk for metastases. The xenotransplantation model is a step toward facilitating precise cellular biologic definition of the metastatic propensity of human NSCLC:

摘要

背景

隐匿性微转移可能解释了I期非小细胞肺癌（NSCLC）患者在完全切除术后的死亡原因。如果能够识别出存在隐匿性转移的患者，全身治疗可能会有益处。

方法

将81例I、II和III期非小细胞肺癌移植到裸米色小鼠体内。平均随访时间为22.5个月（2至61个月）。

结果

21例异种移植成功，7例在裸鼠体内发生转移。主要细胞类型和淋巴结转移发生率均与异种移植结果无关。在21例NSCLC在异种移植中成功的患者中，13例（61.9%）发生了转移，9例（42.9%）死于癌症。在57例NSCLC未成功的患者中，14例（24.6%）发生了转移，9例（15.8%）死于癌症。与异种移植成功相关的转移发生率更高，差异有统计学意义（p = 0.0032）。