Wang X, Fu X, Kubota T, Hoffman R M
AntiCancer, Inc., San Diego, California 92110.
Anticancer Res. 1992 Sep-Oct;12(5):1403-6.
A new nude-mouse metastasizing orthotopic transplant model of human small-cell carcinoma of the lung is described. Histologically-intact human small-cell lung tumors were transplanted to the left lung of nude mice via a thoracotomy procedure we have developed. The transplanted tumors grew extensively locally and metastasized to the opposite lung, lymph nodes and other clinically-relevant sites. The results described indicate the model developed could have clinical relevance and contrasts with models of small-cell carcinoma constructed with injections of cell suspensions which result in few or no metastases.
本文描述了一种新的人小细胞肺癌裸鼠原位转移移植模型。通过我们开发的开胸手术，将组织学完整的人小细胞肺癌肿瘤移植到裸鼠的左肺。移植的肿瘤在局部广泛生长，并转移到对侧肺、淋巴结和其他临床相关部位。所述结果表明，所开发的模型可能具有临床相关性，与注射细胞悬液构建的小细胞癌模型形成对比，后者很少或不发生转移。
