Kendler K S, Pedersen N L, Neale M C, Mathé A A
Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298, USA.
Behav Genet. 1995 May;25(3):217-32. doi: 10.1007/BF02197180.
We investigated the heritability of liability to affective illness (AI) in twins ascertained through psychiatric hospitalization for AI from the Swedish Psychiatric Twin Registry and from the general population Swedish Twin Registry. Lifetime diagnoses were assessed by mailed questionnaire containing, in self-report format, DSM-III-R criteria for mania and major depression (MD). Jointly analyzing both subsamples using Mx, and assuming a multifactorial threshold model, the best-fitting twin model using narrow diagnostic criteria suggested that the liability to AI could be explained by additive genetic effects, with an estimated heritability of liability of 64%, and individual-specific environment. Using broad criteria, results were similar except that the estimated broad heritability of liability was higher (83%) and due largely to dominance genetic effects. Fitting sex-dependent models suggested that the same genetic and environmental factors influenced liability to AI in men and women to the same degree, although women had a lower threshold of manifestation. These results suggested that in Sweden, AI is a highly heritable syndrome and family resemblance is due largely or entirely to genetic factors.
我们通过瑞典精神病学双胞胎登记处和瑞典普通人群双胞胎登记处，对因情感性疾病（AI）住院治疗的双胞胎进行研究，以探究情感性疾病易感性的遗传度。通过邮寄包含以自我报告形式呈现的DSM-III-R躁狂和重度抑郁（MD）标准的问卷，对终生诊断进行评估。使用Mx对两个子样本进行联合分析，并假设采用多因素阈值模型，使用狭义诊断标准的最佳拟合双胞胎模型表明，情感性疾病易感性可由加性遗传效应解释，易感性的估计遗传度为64%，以及个体特异性环境。使用广义标准时，结果相似，只是易感性的估计广义遗传度更高（83%），且主要归因于显性遗传效应。拟合性别依赖性模型表明，相同的遗传和环境因素对男性和女性情感性疾病易感性的影响程度相同，尽管女性的表现阈值较低。这些结果表明，在瑞典，情感性疾病是一种高度可遗传的综合征，家族相似性主要或完全归因于遗传因素。
