转化生长因子-β加速了胶原基质诱导的骨髓细胞的成骨分化。
TGF-beta accelerated the osteogenic differentiation of bone marrow cells induced by collagen matrix.
作者信息
Mizuno M, Kuboki Y
机构信息
Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan.
出版信息
Biochem Biophys Res Commun. 1995 Jun 26;211(3):1091-8. doi: 10.1006/bbrc.1995.1923.
Bone marrow cells have multipotency for differentiation. Recently we found that type I collagen matrix induced the osteogenic differentiation of bone marrow cells. In this study we showed that TGF-beta enhanced the effect of collagen matrix on bone marrow cells and accelerated the osteogenic differentiation. These results imply that TGF-beta might play a crucial role in the osteogenic differentiation of bone marrow cells during embryogenesis and the repair of bone.
骨髓细胞具有多向分化潜能。最近我们发现，I型胶原基质可诱导骨髓细胞向成骨细胞分化。在本研究中，我们表明转化生长因子-β（TGF-β）增强了胶原基质对骨髓细胞的作用，并加速了成骨分化。这些结果表明，TGF-β可能在胚胎发育和骨修复过程中骨髓细胞的成骨分化中起关键作用。
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