人类VNTR基因座D1S80 5'侧翼区域的HinfI多态性。
A HinfI polymorphism in the 5' flanking region of the human VNTR locus D1S80.
作者信息
Alonso A, Martin P, Albarrán C, Sancho M
机构信息
Instituto Nacional de Toxicologia, Sección de Biología, Madrid, Spain.
出版信息
Int J Legal Med. 1995;107(4):216-8. doi: 10.1007/BF01428410.
A restriction fragment length polymorphism (RFLP) characterized by the presence (HinfI+) or absence (HinfI-) of a HinfI site has been found in the 5' flanking region of the VNTR locus D1S80. RFLP-allele frequencies were determined from 82 unrelated individuals: HinfI+ = 0.49, HinfI- = 0.51. The RFLP/VNTR haplotype frequencies show an absolute association between the HinfI+ allele and the VNTR allele of 18 repeat units and an extreme association between the HinfI- allele and the VNTR allele of 24 repeat units. The remaining VNTR alleles associate more randomly with the 2 flanking HinfI alleles.
在VNTR基因座D1S80的5'侧翼区域发现了一种限制性片段长度多态性（RFLP），其特征为存在（HinfI +）或不存在（HinfI -）HinfI位点。从82名无关个体中确定了RFLP等位基因频率：HinfI + = 0.49，HinfI - = 0.51。RFLP / VNTR单倍型频率显示HinfI +等位基因与18个重复单位的VNTR等位基因之间存在绝对关联，HinfI -等位基因与24个重复单位的VNTR等位基因之间存在极端关联。其余VNTR等位基因与两个侧翼HinfI等位基因的关联更为随机。
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