Shimada Y, Masayuki I
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Hum Cell. 1994 Dec;7(4):193-8.
The predictability of the monolayer culture patterning of primary cell culture as an indicator of biological malignancy was described. The prognosis of patients whose cancer cells could grow in monolayer epithelial pattern were significantly lower than that of the "no tumor growth" group. Multivariate analysis indicated that monolayer culture status best correlated with a mortality rate nearly equivalent to the number of lymph node metastasis, and Akaike's information criterion revealed that monolayer epithelial growth is a predictive factor of hematogenous recurrence. The relation of oncogenes and suppressor genes to cell culture was also described. Monolayer epithelial growth may be indicative of such general characteristics as adhesion, motility, invasion and reproduction of cancer cells.
