High renin arterial hypertension due to occlusion of the adrenal veins in the rat.

The direct adreno-renal vascular connection allows precise control of the kidney function by hormones produced by the adrenal gland, without any significant changes in their content in the whole blood. The purpose of the present study is to investigate the effect of the increased blood flow through the vascular network on the blood pressure. In twelve Wistar rats the central adrenal veins were ligated bilaterally. This procedure resulted in chronic increase in systolic blood pressure. This model of arterial hypertension is characterized by high plasma renin activity and normal aldosterone plasma concentration.