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大鼠肾上腺静脉闭塞所致高肾素性动脉高血压

High renin arterial hypertension due to occlusion of the adrenal veins in the rat.

作者信息

Abramczyk P, Przybylski J, Lisiecka A, Papierski K, Ciszek B

机构信息

Department of Physiology, Medical Academy, Warsaw, Poland.

出版信息

J Physiol Pharmacol. 1995 Mar;46(1):71-6.

PMID:7599340
Abstract

The direct adreno-renal vascular connection allows precise control of the kidney function by hormones produced by the adrenal gland, without any significant changes in their content in the whole blood. The purpose of the present study is to investigate the effect of the increased blood flow through the vascular network on the blood pressure. In twelve Wistar rats the central adrenal veins were ligated bilaterally. This procedure resulted in chronic increase in systolic blood pressure. This model of arterial hypertension is characterized by high plasma renin activity and normal aldosterone plasma concentration.

摘要

肾上腺与肾脏之间的直接血管连接使得肾上腺产生的激素能够精确控制肾脏功能,而全血中这些激素的含量并无显著变化。本研究的目的是探讨通过血管网络增加的血流量对血压的影响。在12只Wistar大鼠中,双侧结扎肾上腺中央静脉。该操作导致收缩压慢性升高。这种动脉高血压模型的特点是血浆肾素活性高,醛固酮血浆浓度正常。

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