Hussein A M, Stuart A, Peters W P
Bone Marrow Transplant Program, Duke University Medical Center, Durham, N.C., USA.
Dermatology. 1995;190(3):192-6. doi: 10.1159/000246683.
We have previously shown that several agents will protect against chemotherapy-induced alopecia in the newborn rat animal model. Such protective agents render the hair follicle keratinocytes resistant to chemotherapy possibly by the expression of P-glycoprotein (Pgp). Cyclosporin A (CSA) is a potent inhibitor of Pgp.
Efficacy of CSA was tested in its effects on chemotherapy-induced alopecia in the newborn rat animal model. CSA, when applied topically, protected rats from local alopecia induced by various agents.
The mechanism of protection by CSA and its relationship to Pgp remain uncertain. The potential clinical applicability of this observation remains to be determined.
我们之前已经表明，在新生大鼠动物模型中，几种药物可预防化疗诱导的脱发。此类保护剂可能通过P-糖蛋白（Pgp）的表达使毛囊角质形成细胞对化疗产生抗性。环孢素A（CSA）是一种有效的Pgp抑制剂。
在新生大鼠动物模型中测试了CSA对化疗诱导脱发的影响。局部应用CSA可保护大鼠免受各种药物诱导的局部脱发。
CSA的保护机制及其与Pgp的关系仍不明确。这一观察结果的潜在临床适用性有待确定。
