Niebyl J R, Blake D A, Freeman J M, Luff R D
Obstet Gynecol. 1979 Jan;53(1):139-40.
An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation. Blood levels of primidone decreased during pregnancy and rose postpartum requiring dosage adjustments. Pharmacologically insignificant amounts of the drug were detected in breast milk. A review of the literature revealed 94 infants exposed to carbamazepine in utero and no evidence to date that this drug carries a teratogenic risk.
一名癫痫患者在整个孕期和哺乳期都在接受监测，其癫痫发作通过卡马西平和扑米酮得到控制。扑米酮的血药浓度在孕期降低，产后升高，需要调整剂量。母乳中检测到的药物量在药理学上无显著意义。文献回顾显示，有94名婴儿在子宫内接触过卡马西平，迄今为止没有证据表明该药物有致畸风险。
