Benetello P, Furlanut M
Int J Clin Pharmacol Res. 1987;7(2):165-8.
A 15-year old boy, suffering from partial complex seizures, was treated with primidone (PR) and carbamazepine (CBZ). In spite of daily doses in the usual range (PR = 12 mg/kg, CBZ = 30 mg/kg), he was not free from seizures and serum levels of CBZ were remarkably low (4.8 micrograms/ml). A good control of seizures was obtained after gradually stopping treatment with PR. This lead to a substantial increase of CBZ serum levels to a decrease of carbamazepine-10, 11-epoxide levels and a 60% reduction in total CBZ clearance.
一名15岁患有部分性癫痫发作的男孩接受了扑米酮（PR）和卡马西平（CBZ）治疗。尽管每日剂量在通常范围内（PR = 12毫克/千克，CBZ = 30毫克/千克），但他仍有癫痫发作，且CBZ血清水平显著偏低（4.8微克/毫升）。在逐渐停用PR治疗后，癫痫发作得到了良好控制。这导致CBZ血清水平大幅升高，卡马西平-10,11-环氧化物水平降低，CBZ总清除率降低了60%。
