Schmid M H, Korting H C
Department of Dermatology, Ludwig-Maximilians-University, München, Germany.
Crit Rev Ther Drug Carrier Syst. 1994;11(2-3):97-118.
During the last three decades, the value of liposomes as a drug delivery system has been examined. The interest in liposomes as carriers of active substances is based on their potential to enclose various types of biological materials and to deliver them to diverse cell types. Whereas experiments with systemically applied liposome-entrapped drugs often proved disappointing, recent work suggests that liposomes as vehicles for topical drug delivery may be superior to conventional preparations. The use of liposomes in ophthalmology for the diagnosis and treatment of different ocular diseases has been postulated recently. Dermatics based on liposomes as drug carrier systems have been tested for different types of ingredients, e.g., corticosteroids and local anesthetics. To understand more about the pharmacological potential of liposomes, it is important to investigate the interaction between liposomes and the epidermis. Analysis in this field suggests that only a compromised epidermal barrier enables intact liposomes to penetrate the skin. This is in accordance with clinical findings. A liposomal preparation of betamethasone dipropionate seems superior to a conventional commercial preparation in eczema but not in psoriasis vulgaris. However, one cannot rule out the follicular pathway as an alternate route. Many questions must be resolved before a complete understanding of liposomes as a drug carrier system in dermatology can be reached. However, examinations performed so far indicate that liposomes might be useful as vehicles for topical drug delivery in various diseases of the skin.
在过去三十年中，脂质体作为一种药物递送系统的价值已得到研究。对脂质体作为活性物质载体的兴趣基于其包裹各种生物材料并将其递送至不同细胞类型的潜力。尽管全身应用脂质体包裹药物的实验往往令人失望，但最近的研究表明，脂质体作为局部药物递送的载体可能优于传统制剂。最近有人提出将脂质体用于眼科诊断和治疗不同的眼部疾病。基于脂质体作为药物载体系统的皮肤科制剂已针对不同类型的成分进行了测试，例如皮质类固醇和局部麻醉剂。为了更深入了解脂质体的药理潜力，研究脂质体与表皮之间的相互作用非常重要。该领域的分析表明，只有受损的表皮屏障才能使完整的脂质体穿透皮肤。这与临床发现一致。倍他米松二丙酸酯脂质体制剂在湿疹中似乎优于传统商业制剂，但在寻常型银屑病中并非如此。然而，不能排除毛囊途径作为替代途径。在全面了解脂质体作为皮肤科药物载体系统之前，许多问题必须得到解决。然而，迄今为止进行的研究表明，脂质体可能作为局部药物递送载体用于各种皮肤疾病。
