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1
Direct evidence for uptake of intact liposomes encapsulating silver sulfadiazine by cultured human keratinocytes based on combined transmission electron microscopy and X-ray microanalysis.基于透射电子显微镜和X射线微分析联用的方法，对培养的人角质形成细胞摄取包裹磺胺嘧啶银的完整脂质体的直接证据。
Antimicrob Agents Chemother. 1997 Mar;41(3):717-9. doi: 10.1128/AAC.41.3.717.
2
Interaction of cultured human keratinocytes with liposomes encapsulating silver sulphadiazine: proof of the uptake of intact vesicles.培养的人角质形成细胞与包裹磺胺嘧啶银的脂质体的相互作用：完整囊泡摄取的证据。
Br J Dermatol. 1996 Mar;134(3):445-50.
3
Scar-localized argyria secondary to silver sulfadiazine cream.继发于磺胺嘧啶银乳膏的瘢痕局部银沉着症。
J Am Acad Dermatol. 2003 Oct;49(4):730-2. doi: 10.1067/s0190-9622(02)61574-9.
4
The side effects of silver sulfadiazine.磺胺嘧啶银的副作用。
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5
[Increased serum and urinary levels of silver during treatment with topical silver sulfadiazine].[使用局部磺胺嘧啶银治疗期间血清和尿液中银水平升高]
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Liposome-encapsulated silver sulfadiazine (SSD) for the topical treatment of infected burns: thermodynamics of drug encapsulation and kinetics of drug release.脂质体包裹的磺胺嘧啶银（SSD）用于感染烧伤的局部治疗：药物包裹的热力学和药物释放动力学
J Inorg Biochem. 1995 Nov 15;60(3):187-98. doi: 10.1016/0162-0134(95)00019-k.
7
Development and evaluation of silver sulfadiazine loaded microsponge based gel for partial thickness (second degree) burn wounds.载磺胺嘧啶银微海绵凝胶用于浅二度烧伤创面的研制与评价
Eur J Pharm Sci. 2017 Jan 1;96:243-254. doi: 10.1016/j.ejps.2016.09.038. Epub 2016 Sep 30.
8
Comparison of silver-coated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and silver sulfadiazine 1% (Silverdin) for topical antibacterial effect in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats.银涂层敷料（Acticoat）、0.5%醋酸氯己定（Bactigrass）和1%磺胺嘧啶银（Silverdin）对大鼠铜绿假单胞菌污染的全层皮肤烧伤创面局部抗菌效果的比较。
J Burn Care Rehabil. 2005 Sep-Oct;26(5):430-3. doi: 10.1097/01.bcr.0000176879.27535.09.
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Evidence for the phagocytosis of intact oligolamellar liposomes by human keratinocytes in vitro and consecutive intracellular disintegration.人角质形成细胞在体外对完整的寡层脂质体进行吞噬作用及随后细胞内解体的证据。
J Microencapsul. 1993 Apr-Jun;10(2):223-8. doi: 10.3109/02652049309104388.
10
[Clinical efficacy of silver sulfadiazine (AgSD: Geben cream) for ulcerative skin lesions infected with MRSA].磺胺嘧啶银（AgSD：格本乳膏）治疗耐甲氧西林金黄色葡萄球菌感染的溃疡性皮肤损伤的临床疗效
Jpn J Antibiot. 1997 Jan;50(1):39-44.

本文引用的文献

1
Gluteal pigmentation after intramuscular iron injections.肌肉注射铁剂后臀部色素沉着。
Dermatology. 1996;192(2):187-8. doi: 10.1159/000246357.
2
Interaction of cultured human keratinocytes with liposomes encapsulating silver sulphadiazine: proof of the uptake of intact vesicles.培养的人角质形成细胞与包裹磺胺嘧啶银的脂质体的相互作用：完整囊泡摄取的证据。
Br J Dermatol. 1996 Mar;134(3):445-50.
3
Cytotoxicity to human leukocytes by topical antimicrobial agents used for burn care.用于烧伤护理的局部抗菌剂对人白细胞的细胞毒性。
J Burn Care Rehabil. 1993 Mar-Apr;14(2 Pt 1):132-40. doi: 10.1097/00004630-199303000-00002.
4
A kinetic study of L-2H3-methyl-1-13C-methionine in patients with severe burn injury.严重烧伤患者L-2H₃-甲基-1-¹³C-蛋氨酸的动力学研究。
J Trauma. 1993 Jul;35(1):1-7. doi: 10.1097/00005373-199307000-00001.
5
Silver sulphadiazine: a comprehensive in vitro reassessment.磺胺嘧啶银：全面的体外重新评估
Chemotherapy. 1993 Nov-Dec;39(6):405-9. doi: 10.1159/000238985.
6
Liposomes: a drug carrier system for topical treatment in dermatology.脂质体：一种用于皮肤科局部治疗的药物载体系统。
Crit Rev Ther Drug Carrier Syst. 1994;11(2-3):97-118.
7
Occupational argyria; light and electron microscopic studies and X-ray microanalysis.职业性银质沉着病；光镜和电镜研究及X射线微量分析
Br J Dermatol. 1981 Jan;104(1):19-26. doi: 10.1111/j.1365-2133.1981.tb01706.x.
8
Histochemical demonstration of heavy metals with the sulfide-silver method. A methodological study.用硫化银法对重金属进行组织化学显示：一项方法学研究。
Acta Histochem. 1968;31(2):345-57.
9
In vitro toxicity of topical antimicrobial agents to human fibroblasts.局部用抗菌剂对人成纤维细胞的体外毒性
J Surg Res. 1989 Mar;46(3):267-74. doi: 10.1016/0022-4804(89)90069-3.
10
In vitro toxicity testing for antibacterials against human keratinocytes.抗菌剂对人角质形成细胞的体外毒性测试。
Plast Reconstr Surg. 1991 May;87(5):917-24. doi: 10.1097/00006534-199105000-00017.

基于透射电子显微镜和X射线微分析联用的方法，对培养的人角质形成细胞摄取包裹磺胺嘧啶银的完整脂质体的直接证据。

Direct evidence for uptake of intact liposomes encapsulating silver sulfadiazine by cultured human keratinocytes based on combined transmission electron microscopy and X-ray microanalysis.

作者信息

Schaller M, Wurm R, Korting H C

机构信息

Department of Dermatology, Ludwig Maximilians University, Munich, Germany.

出版信息

Antimicrob Agents Chemother. 1997 Mar;41(3):717-9. doi: 10.1128/AAC.41.3.717.

DOI:10.1128/AAC.41.3.717
PMID:9056023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163781/
Abstract

Cultured human keratinocytes were exposed to liposomally encapsulated silver sulfadiazine, free silver sulfadiazine, silver sulfadiazine cream, and a corresponding vehicle for 5 min to 24 h. Phagocytosis of intact liposomes by keratinocytes was demonstrated in vitro by combined X-ray microanalysis and electron microscopy. Silver as an active part of the antimicrobial served as an electron-dense marker.

摘要

将培养的人角质形成细胞暴露于脂质体包裹的磺胺嘧啶银、游离磺胺嘧啶银、磺胺嘧啶银乳膏以及相应的赋形剂中5分钟至24小时。通过结合X射线微量分析和电子显微镜在体外证实了角质形成细胞对完整脂质体的吞噬作用。作为抗菌活性成分的银充当电子致密标记物。