Weaver D R, Roca A L, Reppert S M
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA.
Brain Res Dev Brain Res. 1995 Apr 18;85(2):293-7. doi: 10.1016/0165-3806(95)00016-7.
We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.
我们研究了孕20天母鼠注射可卡因后胎鼠视交叉上核（SCN）中c-fos和jun-B mRNA的表达时间进程。可卡因处理（30mg/kg）后，c-fos和jun-B mRNA水平在20分钟内升高，40分钟时达到峰值，120分钟时降至基线水平。在小鼠中，D1-多巴胺激动剂SKF 38393可诱导胎鼠SCN和纹状体中的c-fos和jun-B mRNA表达。胎鼠SCN中即时早期基因的调控表达可能在胎儿生物钟的同步化中起作用。
