Tenhagen B A, Bollwahn W, Seidler M J
Klinik für kleine Klauentiere und forensische Medizin, Tierärztlichen Hochschule Hannover.
Dtsch Tierarztl Wochenschr. 1995 Feb;102(2):86-90.
In two vaccination trials the influence of different vaccination schedules of gifts on the colostral immunity of their offspring and the influence of maternally derived antibodies on the active formation of antibodies after vaccination in weanlings were tested. It could be shown, that vaccination of gifts 6 and 3 weeks prior to farrowing led to higher blood levels of maternally derived antibodies in their offspring than vaccination earlier during gestation or prior to mating. Correlation between antibody level of sow, colostrum and offspring was good, the halflife of the antibodies was 11.3 days. Low levels of maternally derived antibodies did not influence the active formation of antibodies after vaccination, higher levels reduced antibody-formation, but did not suppress it completely. Sow colostrum and blood of piglets are generally adequate substrates for the serologic control of breeding units regarding Aujeszky's disease. Existing problems are mentioned. The results of this study are discussed concerning their importance for the eradication of Aujeszky's disease with vaccination programs.
在两项疫苗接种试验中，测试了不同的疫苗接种时间安排对母猪后代初乳免疫力的影响，以及母源抗体对断奶仔猪接种疫苗后抗体主动形成的影响。结果表明，在分娩前6周和3周给母猪接种疫苗，其后代血液中的母源抗体水平高于在妊娠早期或配种前接种疫苗的情况。母猪、初乳和后代的抗体水平之间相关性良好，抗体的半衰期为11.3天。低水平的母源抗体不影响接种疫苗后抗体的主动形成，高水平则会降低抗体形成，但不会完全抑制。母猪初乳和仔猪血液通常是用于对繁殖单元进行伪狂犬病血清学监测的合适样本。文中提到了现存的问题。讨论了本研究结果对于通过疫苗接种计划根除伪狂犬病的重要性。
