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[猪伪狂犬病疫苗接种试验]

[Trial of vaccination against Aujeszky's disease].

作者信息

Motovski A, Veselinova A, Dobrev V

出版信息

Vet Med Nauki. 1980;17(5):32-7.

PMID:6262995
Abstract

An experiment was carried out on pigs during which a passive immunity was created, similar to the colastral one, by injecting a specific for Aujeszky's disease gamma-globulin. After 48 hours the pigs were vaccinated with different quantities of living MK-25 vaccine and were checked for virus neutralizing antibodies against Aujeszky's disease. On the 90th and 180th days after the vaccination they were infected with a virulent virus (10(6) TCIU) and were checked clinically, serologically, virologically and pathomorphologically. It was proved that the pigs who had a passive immunity and were vaccinated with one dose of vaccine, did not build up a stable and active immunity after their vaccination, due to the neutralization of the vaccinal virus by passive immunity. The implementation of higher quantities of vaccine, however, overcame passive immunity and induced the build-up of active immunity after the vaccination.

摘要

在猪身上进行了一项实验,期间通过注射针对奥耶斯基氏病的γ球蛋白产生了一种类似于初乳免疫的被动免疫。48小时后,给猪接种不同剂量的活MK - 25疫苗,并检测其针对奥耶斯基氏病的病毒中和抗体。在接种疫苗后的第90天和180天,用强毒病毒(10(6) TCIU)感染它们,并进行临床、血清学、病毒学和病理形态学检查。结果证明,具有被动免疫且接种一剂疫苗的猪,由于被动免疫中和了疫苗病毒,接种后未建立稳定而活跃的免疫力。然而,使用更高剂量的疫苗则克服了被动免疫,并在接种后诱导产生了活跃的免疫力。

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