Vanderschuren L J, Niesink R J, Spruijt B M, Van Ree J M
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Faculty of Medicine, Utrecht University, The Netherlands.
Eur J Pharmacol. 1995 Apr 4;276(3):257-66. doi: 10.1016/0014-2999(95)00040-r.
Previously, morphine has been shown to influence social play behavior in rats on two levels. An increasing effect on social play was interpreted as an effect on the rewarding aspects of social play. A lower dose of morphine abolished the effects of an unfamiliar environment on social play, supposedly by affecting the integration of environmental stimuli. In the present study the effects of receptor-specific opioid drugs on social play and measures of social behavior unrelated to play were investigated. Fentanyl, a mu-opioid receptor agonist, seemingly mimicked both effects of morphine. The mu-opioid receptor antagonist, beta-funaltrexamine, decreased social play, although a low dose of this drug increased it. BUBUC (Tyr-D-Cys(StBu)-Gly-Phe-Leu-Thr(OtBu)) and naltrindole, a delta-opioid receptor agonist and delta-opioid receptor antagonist, respectively, had no effects on social behavior. The kappa-opioid receptor agonist, U50,488H (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), dose dependently suppressed all measures of social behavior. The kappa-opioid receptor antagonist, nor-binaltorphimine, abolished the effect of an unfamiliar environment on social play. These studies suggest that the opioidergic effect on social play is mediated through mu- and kappa-opioid receptor systems.
此前研究表明，吗啡可在两个层面影响大鼠的社会玩耍行为。对社会玩耍的增强作用被解释为对社会玩耍奖励方面的影响。较低剂量的吗啡消除了陌生环境对社会玩耍的影响，推测是通过影响环境刺激的整合来实现的。在本研究中，研究了受体特异性阿片类药物对社会玩耍以及与玩耍无关的社会行为指标的影响。μ-阿片受体激动剂芬太尼似乎模拟了吗啡的两种作用。μ-阿片受体拮抗剂β-氟纳曲明减少了社会玩耍，尽管低剂量的该药物会增加社会玩耍。分别作为δ-阿片受体激动剂和δ-阿片受体拮抗剂的BUBUC（酪氨酰-D-半胱氨酸（叔丁基）-甘氨酰-苯丙氨酰-亮氨酰-苏氨酸（叔丁酯））和纳曲吲哚对社会行为没有影响。κ-阿片受体激动剂U50,488H（反式-3,4-二氯-N-甲基-N-[2-(1-吡咯烷基)-环己基]-苯乙酰胺）剂量依赖性地抑制了所有社会行为指标。κ-阿片受体拮抗剂去甲二丙诺啡消除了陌生环境对社会玩耍的影响。这些研究表明，阿片类物质对社会玩耍的作用是通过μ-和κ-阿片受体系统介导的。
