Tanaka S, Nishimura M, Kitoh J, Matsuzawa A
Laboratory Animal Research Center, University of Tokyo, Japan.
Exp Anim. 1995 Apr;44(2):127-30. doi: 10.1538/expanim.44.127.
The recombinant inbred (RI) mouse group is useful for genetic analysis of a phenotype which is regulated by multiple loci. The female adrenal cortex was compared histologically to detect the strain differences between A/J and SM/J for the purpose of genetic analysis of adrenocortical morphogenesis using the SMXA RI group constructed between A/J and SM/J. Clear morphological differences were found in the zona reticularis and X zone in addition to the significantly small body and adrenal weights in SM/J. The z. reticularis was markedly thicker in SM/J than in A/J and the X zone was constituted of vacuolated cells in A/J and non-vacuolated cells in SM/J. The genetic control of these morphological traits was analyzed using SMXA RI strains. The results suggest that the thickness of the z. reticularis may be controlled by single locus and that vacuolation of the X zone by 3 different loci between A/J and SM/J.
重组近交（RI）小鼠群体对于受多个基因座调控的表型的遗传分析很有用。为了使用在A/J和SM/J之间构建的SMXA RI群体对肾上腺皮质形态发生进行遗传分析，对雌性肾上腺皮质进行了组织学比较，以检测A/J和SM/J之间的品系差异。除了SM/J的体型和肾上腺重量明显较小外，在网状带和X区还发现了明显的形态差异。SM/J的网状带明显比A/J厚，A/J的X区由空泡化细胞组成，而SM/J的X区由非空泡化细胞组成。使用SMXA RI品系分析了这些形态特征的遗传控制。结果表明，网状带的厚度可能由单个基因座控制，而A/J和SM/J之间X区的空泡化由3个不同的基因座控制。
