Rosenfeld C S, Rybka W B, Weinbaum D, Carrigan D R, Knox K K, Andrews D F, Shadduck R K
Texas Oncology, Dallas, USA.
Exp Hematol. 1995 Jul;23(7):626-9.
Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.
骨髓移植（BMT）后人类疱疹病毒6型（HHV-6）感染的造血效应包括植入延迟和早期骨髓抑制。BMT后未分离出A变体。报告了1例慢性期慢性粒细胞白血病（CML）患者接受HLA配型相合的BMT后发生移植物衰竭的病例。在移植物衰竭期间对骨髓进行评估，通过培养、免疫荧光、聚合酶链反应（PCR）和免疫组织化学检测发现了HHV-6的A和B变体。未发现包括巨细胞病毒（CMV）在内的其他移植物衰竭病例的证据。提出了一种假说，即该病例的晚期移植物衰竭是由HHV-6的A变体所致。
