Braun D K, Dominguez G, Pellett P E
Eli Lilly, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
Clin Microbiol Rev. 1997 Jul;10(3):521-67. doi: 10.1128/CMR.10.3.521.
Human herpesvirus 6 variant A (HHV-6A) and human herpesvirus 6 variant B (HHV-6B) are two closely related yet distinct viruses. These visuses belong to the Roseolovirus genus of the betaherpesvirus subfamily; they are most closely related to human herpesvirus 7 and then to human cytomegalovirus. Over 95% of people older than 2 years of age are seropositive for either or both HHV-6 variants, and current serologic methods are incapable of discriminating infection with one variant from infection with the other. HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. HHV-6B is the etiologic agent of the common childhood illness exanthem subitum (roseola infantum or sixth disease) and related febrile illnesses. These viruses are frequently active and associated with illness in immunocompromised patients and may play a role in the etiology of Hodgkin's disease and other malignancies. HHV-6 is a commensal inhabitant of brains; various neurologic manifestations, including convulsions and encephalitis, can occur during primary HHV-6 infection or in immunocompromised patients. HHV-6 and distribution in the central nervous system are altered in patients with multiple sclerosis; the significance of this is under investigation.
人类疱疹病毒6型A变体（HHV - 6A）和人类疱疹病毒6型B变体（HHV - 6B）是两种密切相关但又有所不同的病毒。这些病毒属于β疱疹病毒亚科的玫瑰疹病毒属；它们与人类疱疹病毒7型关系最为密切，其次与人类巨细胞病毒关系密切。超过95%的2岁以上人群对一种或两种HHV - 6变体血清学检测呈阳性，而目前的血清学方法无法区分感染的是一种变体还是另一种变体。HHV - 6A在病因学上尚未与任何人类疾病相关联，但可能很快会发现这种关联。HHV - 6B是常见儿童疾病幼儿急疹（婴儿玫瑰疹或第六病）及相关发热性疾病的病原体。这些病毒在免疫功能低下的患者中经常活跃并与疾病相关，可能在霍奇金淋巴瘤和其他恶性肿瘤的病因学中起作用。HHV - 6是大脑的共生居民；在原发性HHV - 6感染期间或免疫功能低下的患者中，可能会出现各种神经系统表现，包括惊厥和脑炎。在多发性硬化症患者中，HHV - 6在中枢神经系统中的分布会发生改变；其意义正在研究中。
