Sea T, Ballinger M L, Bittner G D
Department of Zoology, University of Texas at Austin 78712-1064, USA.
Exp Neurol. 1995 May;133(1):85-95. doi: 10.1006/exnr.1995.1010.
The histological and ultrastructural status of intact and severed axons was examined in the ventral tail nerve of rats whose tails were maintained at 32, 23, and 13 degrees C. Compared to contralateral intact nerves, distal (anucleate) portions of severed myelinated axons morphologically and ultrastructurally degenerated within 3 days at 32 degrees C and within 6 days at 23 degrees C. In contrast, anucleate myelinated axons in ventral tail nerves maintained at 13 degrees C did not degenerate for at least 10 days. These and other data suggest that rapid Wallerian degeneration of anucleate myelinated axons is not an inevitable result of axonal severance in mammals.
在将尾巴分别维持在32℃、23℃和13℃的大鼠的腹侧尾神经中，对完整和切断的轴突的组织学和超微结构状态进行了检查。与对侧完整神经相比，切断的有髓轴突的远端（无核）部分在32℃时3天内、23℃时6天内在形态和超微结构上发生退化。相比之下，维持在13℃的腹侧尾神经中的无核有髓轴突至少10天没有退化。这些数据和其他数据表明，无核有髓轴突的快速沃勒变性并非哺乳动物轴突切断的必然结果。
