Sarac Benjamin A, Wordsworth Matthew, Schmucker Ryan W
Department of Plastic and Reconstructive Surgery, the Ohio State University Wexner Medical Center, Columbus, OH.
J Hand Surg Glob Online. 2024 Mar 25;6(5):740-742. doi: 10.1016/j.jhsg.2024.01.016. eCollection 2024 Sep.
Peripheral nerve injuries are potentially devastating injuries leading to pain and impairment in motor and sensory functions. Since the first published use of microsurgical epineural repair of peripheral nerves in 1964, a wide variety of adjuncts have been studied. Polyethylene glycol is a fusogen that has been shown to restore axolemmal membranes. The use of polyethylene glycol in nerve injuries was first described in 1986, and animal studies have shown fusion of transected sensory and motor nerves following early application at the time of surgical repair with improved motor and sensory outcomes. Early human clinical trials have shown promising results, although more data are needed to provide specific indications and protocols. This article summarizes the background, current evidence, and future directions as well as potential applications of polyethylene glycol-mediated nerve fusion.
周围神经损伤是潜在的毁灭性损伤，可导致疼痛以及运动和感觉功能障碍。自1964年首次发表关于周围神经显微外科神经外膜修复的文章以来，人们对各种各样的辅助手段进行了研究。聚乙二醇是一种融合剂，已被证明可修复轴突膜。1986年首次描述了聚乙二醇在神经损伤中的应用，动物研究表明，在手术修复时早期应用聚乙二醇可使横断的感觉神经和运动神经融合，从而改善运动和感觉结果。早期人体临床试验已显示出有前景的结果，不过还需要更多数据来提供具体的适应症和方案。本文总结了聚乙二醇介导的神经融合的背景、当前证据、未来方向以及潜在应用。
