Yost H J, Phillips C R, Boore J L, Bertman J, Whalon B, Danilchik M V
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis 55455, USA.
Dev Biol. 1995 Jul;170(1):83-90. doi: 10.1006/dbio.1995.1197.
Dorsal-ventral axis formation in Xenopus laevis begins with a cytoplasmic rotation during the first cell cycle and culminates in a series of cell interactions and movements during gastrulation and neurulation that lead to the formation of dorsal-anterior structures. Evidence reported here indicates that mitochondria are differentially redistributed along the prospective dorsal-ventral axis as a consequence of the cortical-cytoplasmic rotation during the first cell cycle. This finding reinvigorates a possibility that has been considered for many years: asymmetries in cytoplasmic components and metabolic activities contribute to the development of morphological asymmetries.
非洲爪蟾背腹轴的形成始于第一个细胞周期中的细胞质旋转，并在原肠胚形成和神经胚形成期间的一系列细胞相互作用和运动中达到顶点，这些相互作用和运动导致背前部结构的形成。此处报告的证据表明，由于第一个细胞周期中的皮质细胞质旋转，线粒体沿预期的背腹轴发生差异性重新分布。这一发现重新唤起了一个多年来一直被考虑的可能性：细胞质成分和代谢活动的不对称性有助于形态不对称性的发展。
